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- i. Lippincott Illustrated Reviews: Pharmacology Sixth Edition 0002152327.INDD 1 6/25/2014 seven:27:51 AM
- 2. 0002152327.INDD 2 half-dozen/25/2014 7:27:52 AM
- 3. Lippincott Illustrated Reviews: Pharmacology Sixth Edition Karen Whalen, Pharm.D., BCPS Department of Pharmacotherapy and Translational Research University of Florida College of Pharmacy Gainesville, Florida Collaborating Editors Richard Finkel, Pharm.D. Department of Pharmaceutical Sciences Nova Southeastern University College of Pharmacy Fort Lauderdale, Florida Thomas A. Panavelil, Ph.D., MBA Section of Pharmacology Nova Southeastern University Higher of Medical Sciences Fort Lauderdale, Florida 0002152327.INDD 3 half-dozen/25/2014 vii:27:55 AM
- four. Acquisitions Editor: Tari Broderick Product Development Editor: Stephanie Roulias Product Projection Managing director: Marian A. Bellus Design Coordinator: Holly McLaughlin Analogy Coordinator: Jennifer Clements Manufacturing Coordinator: Margie Orzech Marketing Director: Joy Fisher-Williams Prepress Vendor: SPi Global 6th edition Copyright 2015 Wolters Kluwer Copyright 2012 Wolters Kluwer Health / Lippincott Williams & Wilkins, Copyright 2009 Lippincott Williams & Wilkins, a Wolters Kluwer business, Copyright 2006, 2000 past Lippincott Williams & Wilkins, Copyright 1997 by Lippincott-Raven Publishers, Copyright 1992 by J. B. Lippincott Company. All rights reserved.This book is protected past copyright. No part of this book may exist reproduced or transmitted in any course or by any means, including as photocopies or scanned-in or other electronic copies, or utilized by any information storage and retrieval organisation without written permission from the copyright owner, except for cursory quotations embodied in critical articles and reviews. Materials actualization in this volume prepared by indi- viduals as part of their official duties as U.S. authorities employees are not covered by the higher up-mentioned copyright. To asking permission, please contact Wolters Kluwer Health at Two Commerce Square, 2001 Marketplace Street, Philadelphia, PA 19103, via email at permissions@lww.com, or via our website at lww.com (products and services). 987654321 Printed in China Library of Congress Cataloging-in-Publication Data Pharmacology (Whalen) Pharmacology / [edited by] Karen Whalen ; collaborating editors, Richard Finkel, Thomas A. Panavelil. 6th edition. p. ; cm. (Lippincott illustrated reviews) Includes index. Preceded by Pharmacology / Michelle A. Clark [et al.]. 5th ed. c2012. ISBN 978-1-4511-9177-half-dozen I. Whalen, Karen, editor. Two. Finkel, Richard (Richard S.), editor. 3. Panavelil, Thomas A., editor. Iv.Title. V. Series: Lippincott illustrated reviews. [DNLM: 1. PharmacologyExamination Questions. ii. PharmacologyOutlines. QV 18.2] RM301.fourteen 615.1076dc23 2014021450 This work is provided as is, and the publisher disclaims any and all warranties, limited or implied, includ- ing whatever warranties as to accuracy, comprehensiveness, or currency of the content of this work. This work is no substitute for individual patient cess based upon healthcare professionals' examina- tion of each patient and consideration of, amidst other things, age, weight, gender, electric current or prior medical conditions, medication history, laboratory data and other factors unique to the patient. The publisher does not provide medical advice or guidance and this work is simply a reference tool. Healthcare professionals, and non the publisher, are solely responsible for the utilize of this work including all medical judgments and for whatever resulting diagnosis and treatments. Given continuous, rapid advances in medical science and wellness information, independent professional verification of medical diagnoses, indications, appropriate pharmaceutical selections and dosages, and treatment options should be made and healthcare professionals should consult a variety of sources. When prescribing medication, healthcare professionals are advised to consult the production information sheet (the manufacturer's package insert) accompanying each drug to verify, among other things, conditions of use, warnings and side effects and identify whatsoever changes in dosage schedule or contradictions, particularly if the medication to be administered is new, infrequently used or has a narrow therapeutic range. To the maxi- mum extent permitted under applicative constabulary, no responsibility is causeless by the publisher for any injury and/or damage to persons or property, as a matter of products liability, negligence constabulary or otherwise, or from any reference to or use by whatever person of this work. LWW.com 0002152327.INDD 4 six/25/2014 7:27:55 AM
- five. Contributing Authors Shawn Anderson, Pharm.D., BCACP Department of Pharmacy North Florida/South Georgia VA Medical Middle Gainesville, Florida Angela K. Birnbaum, Ph.D. Department of Experimental and Clinical Pharmacology University of Minnesota College of Pharmacy Minneapolis, Minnesota Nicholas Carris, Pharm.D., BCPS Department of Pharmacotherapy and Translational Research Academy of Florida Colleges of Chemist's and Medicine Gainesville, Florida Lisa Clayville Martin, Pharm.D. Department of Pharmacotherapy and Translational Enquiry University of Florida Higher of Pharmacy Orlando, Florida Patrick Cogan, Pharm.D. Department of Pharmacotherapy and Translational Inquiry University of Florida Higher of Pharmacy Gainesville, Florida Jeannine 1000. Conway, Pharm.D., BCPS Department of Experimental and Clinical Pharmacology Academy of Minnesota College of Chemist's shop Minneapolis, Minnesota Eric Dietrich, Pharm.D., BCPS Department of Pharmacotherapy and Translational Enquiry University of Florida Colleges of Chemist's shop and Medicine Gainesville, Florida Eric Egelund, Pharm.D., Ph.D. Department of Pharmacotherapy and Translational Enquiry University of Florida College of Chemist's shop Gainesville, Florida Richard Finkel, Pharm.D. Section of Pharmaceutical Sciences Nova Southeastern Academy College of Chemist's shop Fort Lauderdale, Florida Timothy P. Gauthier, Pharm.D., BCPS (AQ-ID) Department of Chemist's shop Practise Nova Southeastern University College of Pharmacy Fort Lauderdale, Florida Andrew Hendrickson, Pharm.D. Section of Chemist's shop N Florida/South Georgia VA Medical Middle Gainesville, Florida Jamie Kisgen, Pharm.D., BCPS Section of Pharmacy Sarasota Memorial Health Care System Sarasota, Florida Kourtney LaPlant, Pharm.D., BCOP Section of Chemist's shop North Florida/South Georgia VA Medical Center Gainesville, Florida Paige Louzon, Pharm.D., BCOP Section of Pharmacy North Florida/South Georgia VA Medical Center Gainesville, Florida Kyle Melin, Pharm.D., BCPS Department of Pharmacy Do University of Puerto Rico School of Pharmacy San Juan, Puerto Rico Robin Moorman Li, Pharm.D., BCACP Department of Pharmacotherapy and Translational Research University of Florida College of Chemist's shop Jacksonville, Florida Carol Motycka, Pharm.D., BCACP Department of Pharmacotherapy and Translational Inquiry Academy of Florida College of Pharmacy Jacksonville, Florida Kristyn Mulqueen, Pharm.D., BCPS Department of Pharmacy N Florida/South Georgia VA Medical Eye Gainesville, Florida 5 0002152327.INDD five 6/25/2014 7:27:55 AM
- 6. vi Contributing Authors Thomas A. Panavelil, Ph.D., MBA Department of Pharmacology Nova Southeastern University College of Medical Sciences Fort Lauderdale, Florida Charles A. Peloquin, Pharm.D. Department of Pharmacotherapy and Translational Research University of Florida College of Chemist's shop Gainesville, Florida Joanna Peris, Ph.D. Department of Pharmacodynamics Academy of Florida College of Pharmacy Gainesville, Florida Jason Powell, Pharm.D. Department of Pharmacotherapy and Translational Research University of Florida College of Pharmacy Gainesville, Florida Rajan Radhakrishnan, B.South. Pharm., Grand.S., Ph.D. Roseman University of Health Sciences College of Chemist's shop South Jordan, Utah Jose A. Rey, Pharm.D., BCPP Department of Pharmaceutical Sciences Nova Southeastern University College of Pharmacy Fort Lauderdale, Florida Karen Sando, Pharm.D., BCACP Department of Pharmacotherapy and Translational Inquiry University of Florida Higher of Chemist's shop Gainesville, Florida Elizabeth Sherman, Pharm.D. Department of Pharmacy Practice Nova Southeastern University College of Chemist's shop Fort Lauderdale, Florida Dawn Sollee, Pharm.D., DABAT Florida/USVI Poison Information Eye UF Wellness Jacksonville Jacksonville, Florida Joseph Spillane, Pharm.D., DABAT Department of Chemist's UF Health Jacksonville Jacksonville, Florida Sony Tuteja, Pharm.D., BCPS Section of Medicine Perelman School of Medicine at the University of Pennsylvania Philadelphia, Pennsylvania Nathan R. Unger, Pharm.D. Section of Pharmacy Practise Nova Southeastern University College of Pharmacy Palm Embankment Gardens, Florida Katherine Vogel Anderson, Pharm.D., BCACP Section of Pharmacotherapy and Translational Research Academy of Florida Colleges of Pharmacy and Medicine Gainesville, Florida Karen Whalen, Pharm.D., BCPS Department of Pharmacotherapy and Translational Research University of Florida College of Pharmacy Gainesville, Florida Thomas B. Whalen, Thou.D. Diplomate, American Board of Anesthesiology Ambulatory Anesthesia Consultants, PLLC Gainesville, Florida Venkata Yellepeddi, B.S. Pharm, Ph.D. Roseman Academy of Health Sciences College of Pharmacy South Jordan, Utah 0002152327.INDD half-dozen 6/25/2014 7:27:55 AM
- 7. Reviewer Ashley Castleberry, Pharm.D., Yard.A.Ed. University of Arkansas for Medical Sciences College of Chemist's Fiddling Stone, Arkansas Analogy and Graphic Design Michael Cooper Cooper Graphic www.cooper247.com Claire Hess hess2 Design Louisville, Kentucky seven 0002152327.INDD seven 6/25/2014 7:27:56 AM
- viii. 0002152327.INDD 8 6/25/2014 vii:27:56 AM
- ix. Contributing Authors v Reviewer vii Illustration and Graphic Designvii Unit I: Principles of Drug Therapy Chapter 1: Pharmacokin
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